Published November 5, 2025
Communications Biology · Nature Portfolio
Neural and Molecular Changes During a Mind-Body Reconceptualization, Meditation, and Open-Label Placebo Healing Intervention
Jinich-Diamant A, Garland E, Baumgartner N, Gonzalez N, Quazi G, Castejon J, Rosenberg JT, Klinger D, Baker SD, Griffith M, Licamele M, Chernov M, Amkie Stahl NE, Fazlalipour N, Devulapalli S, Christov-Moore L, Reggente N, Poirier MA, Moeller-Bertram T, Patel HH
Abstract
This study investigated the neural and molecular effects of a 7-day retreat combining meditation, reconceptualization, and open-label placebo healing rituals in 20 healthy participants. Using BOLD fMRI, plasma proteomics (7,596 proteins), metabolomics (640 metabolites), and cellular assays, the researchers found:
- Meditation decreased default mode network and salience network connectivity
- Post-retreat plasma increased neurite outgrowth and glycolytic metabolism in cultured neurons
- Upregulated BDNF pathway, inflammatory and anti-inflammatory markers, and endogenous opioid pathways
- Brain connectivity patterns resembled those seen with psychedelics like psilocybin — achieved through meditation alone
Conclusion: An intensive non-pharmacological intervention produced broad neural and peripheral molecular changes suggestive of enhanced neuroplasticity, metabolic reprogramming, and immune/opioid modulation.